光动力疗法中光动力剂量的数学仿真研究

徐朝辉;贺庆丽

应用光学 ›› 2010, Vol. 31 ›› Issue (3) : 512-516.

应用光学 ›› 2010, Vol. 31 ›› Issue (3) : 512-516.

光动力疗法中光动力剂量的数学仿真研究

  • 徐朝辉1,2, 贺庆丽1
作者信息 +

Photodynamic dose of photodynamic therapy by mathematical simulation

  • XU Zhao-hui1,2, HE Qing-li1
Author information +
文章历史 +

摘要

通过建立光动力治疗过程中激光、光敏剂、氧及其相互作用关系的数学模型,对组织中光动力剂量进行了模拟,研究了光动力剂量在组织内部分布变化的规律。模拟了激光剂量为50mW/cm2、100mW/cm2、150mW/cm2,光敏剂质量浓度为10mg/kg、20mg/kg、40mg/kg时光动力剂量变化。研究发现光动力剂量在组织内分布是非线性的,大小受激光强度、光敏剂剂量、氧浓度和组织光学参数等因素的影响,且光敏剂浓度的变化对光动力剂量变化的影响尤为明显。

Abstract

Through establishing mathematical relation model of laser, photo-sensitizer and oxygen, photodynamic dose (PDD) in tissue was simulated and its distribution was studied. The change of PDD under the different laser doses of 50mW/cm2,100mW/cm2 and 150mW/cm2 and the photo-sensitizer concentrations of 10mg/kg,20mg/kg and 40mg/kg were simulated. It is concluded that the PDD, an inhomogeneous value in the tissue, changes with many factors such as laser dose, photo-sensitizer and oxygen, and it is obviously effected by the variation of photo-sensitizer concentration.

关键词

肿瘤组织 / 光动力剂量 / 光漂白 / 光动力疗法

Key words

photodynamic therapy / PDD / photo-bleaching / tissue

引用本文

导出引用
徐朝辉, 贺庆丽. 光动力疗法中光动力剂量的数学仿真研究. 应用光学. 2010, 31(3): 512-516
XU Zhao-hui, HE Qing-li. Photodynamic dose of photodynamic therapy by mathematical simulation. Journal of Applied Optics. 2010, 31(3): 512-516

参考文献

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