通过建立光动力治疗过程中激光、光敏剂、氧及其相互作用关系的数学模型,对组织中光动力剂量进行了模拟,研究了光动力剂量在组织内部分布变化的规律。模拟了激光剂量为50mW/cm2、100mW/cm2、150mW/cm2,光敏剂质量浓度为10mg/kg、20mg/kg、40mg/kg时光动力剂量变化。研究发现光动力剂量在组织内分布是非线性的,大小受激光强度、光敏剂剂量、氧浓度和组织光学参数等因素的影响,且光敏剂浓度的变化对光动力剂量变化的影响尤为明显。
Abstract
Through establishing mathematical relation model of laser, photo-sensitizer and oxygen, photodynamic dose (PDD) in tissue was simulated and its distribution was studied. The change of PDD under the different laser doses of 50mW/cm2,100mW/cm2 and 150mW/cm2 and the photo-sensitizer concentrations of 10mg/kg,20mg/kg and 40mg/kg were simulated. It is concluded that the PDD, an inhomogeneous value in the tissue, changes with many factors such as laser dose, photo-sensitizer and oxygen, and it is obviously effected by the variation of photo-sensitizer concentration.
关键词
肿瘤组织 /
光动力剂量 /
光漂白 /
光动力疗法
{{custom_keyword}} /
Key words
photodynamic therapy /
PDD /
photo-bleaching /
tissue
{{custom_keyword}} /
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1]JULIA G L. Photodynamic therapy[J]. Tibtech Jan-uary, 1995,13(3):14-18.
[2]李忠明,张镇西.光动力作用效果的剂量学描述探讨[J].激光杂志,2005,26(5):91-92.
LI Ming-zhong,ZHANG Zhen-xi. Description of dosage on photodynamic therapy effect[J]. Laser Journal,2005,26(5):91-92.(in Chinese with an English abstract)
[3]WANG K K,LUTZKE L,BORKENHAGEN L, et al. Photodynamic therapy for Barrett’s esophagus: does light still have a role?[J]. Endoscopy, 2008,40(6):1021-1025.
[4]SVAASAND L O, WYSS P, WYSS M T, et al. Dosimetry model for photodynamic therapy with topically administered photosensitizers[J]. Lasers in Surgery and Medicine,2009,41(1):21-32.
[5]MARIA C, DEROSA, ROBERT J. Photosensitized singlet oxygen and its applications[J].Crutchley Coordination Chemistry Reviews,2009,30(1):351-371.
[6]ANDREEA D, ZHU T C, HAHN S M, et al. In vivo light dosimetry for motexafin lutetium-mediated PDT of recur
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}